GABA quantitation using MEGA-PRESS: Regional and hemispheric differences
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چکیده
منابع مشابه
GABA quantitation using MEGA-PRESS: Regional and hemispheric differences.
PURPOSE To measure in vivo brain gamma-aminobutyric acid (GABA) concentrations, and assess regional and hemispheric differences, using MR spectroscopy (1 H-MRS). MATERIALS AND METHODS GABA concentrations were measured bilaterally in the frontal cortex (FC), parietal cortex (PC), and occipital cortex (OC) of 21 healthy young subjects (age range 20-29 years) using 3 Tesla Philips scanner. A uni...
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Introduction: GABA (γ-aminobutyric acid) is a primary inhibitory neurotransmitter in the human brain and the object of many a spectroscopic quest. A MEGAPRESS sequence [1] with TE=68 ms and interleaved selective inversion at 1.9 ppm and 7.5 ppm has been shown to be a useful technique for measuring GABA at 3T, and LCModel [2] can then be used to analyze the resulting difference spectra. A compli...
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γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS). In a GABA-edited MEGA-PRESS spectrum, Glu and Gln co-...
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U. Dydak, J. S. Xu, M. Marjanska, and S. Posse School of Health Sciences, Purdue University, West Lafayette, IN, United States, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, Center for Magnetic resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, Department of Neurology, U...
متن کاملGABA Fitting for MEGA-PRESS Sequences with Different Selective Inversion Frequencies
Introduction GABA detection faces the problem of contamination from co-edited macromolecule signal at 3.0 ppm (MM30) when using the MEGA-PRESS technique [1]. Therefore, direct quantification of GABA by LCModel software [2] yields the sum of GABA and MM30. One of the proposed methods to eliminate MM30 is to alternate the editing pulse between 1.9 ppm and 1.5 ppm, the latter a position symmetric ...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance Imaging
سال: 2016
ISSN: 1053-1807
DOI: 10.1002/jmri.25324